Late-onset Patients with Sporadic Amyotrophic Lateral Sclerosis in Japan have a Higher Progression Rate of ALSFRS-R at the Time of Diagnosis
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- Tanaka Yuji
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Yoshikura Nobuaki
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Harada Naoko
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Yamada Megumi
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Koumura Akihiro
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Sakurai Takeo
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Hayashi Yuichi
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Kimura Akio
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Hozumi Isao
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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- Inuzuka Takashi
- Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
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抄録
Objective The population in Japan is aging at a faster rate than in other countries in the world. It is speculated that the number of patients with late-onset amyotrophic lateral sclerosis (ALS) will increase even more in the future. However, few studies have been undertaken on the characteristics of patients with late-onset ALS in Japan. This study sought to investigate the clinical features of patients with late-onset ALS compared with those with early-onset ALS using the progression rate (ΔFS).<br> Methods Forty-five patients with sporadic ALS were divided into 2 groups: 23 patients with early-onset of ALS (<65 years; early onset) and 22 patients with late-onset ALS (≥65 years; late onset). Every patient was followed up from the time of initial diagnosis to the primary endpoint (death or time culminating in death without tracheostomy or ventilation assistance including noninvasive positive pressure ventilation) or for at least 48 months after initial diagnosis.<br> Results ΔFS in the patient group with late onset was significantly higher than that of the group with early onset (p=0.010). Survival of patients with late onset was significantly decreased compared to that of patients with early onset (p=0.031).<br> Conclusion Our finding suggested that patients with late-onset ALS showed more rapid disease progression than those with early-onset ALS using ΔFS.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (6), 579-584, 2012
一般社団法人 日本内科学会