Pulmonary Veno-occlusive Disease Following Reduced-intensity Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

  • Hosokawa Kohei
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
  • Yamazaki Hirohito
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
  • Nishitsuji Masaru
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
  • Kobayashi Satoshi
    Department of Radiology, Kanazawa University School of Medicine, Japan
  • Takami Akiyoshi
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
  • Fujimura Masaki
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan
  • Nakao Shinji
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Japan

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抄録

We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (2), 195-198, 2012

    一般社団法人 日本内科学会

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