Chronic Inflammatory Demyelinating Polyneuropathy Due to the Administration of Pegylated Interferon .ALPHA.-2b: A Neuropathology Case Report

DOI Web Site 1 Citations 15 References
  • Shiga Kensuke
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan
  • Tanaka Eijiroh
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan
  • Isayama Reina
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan
  • Mizuno Toshiki
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan
  • Itoh Kyoko
    Department of Molecular Pathology, Kyoto Prefectural University of Medicine, Japan
  • Nakagawa Masanori
    Department of Neurology, Kyoto Prefectural University of Medicine, Japan

Search this article

Abstract

We report a 35-year-old man who developed weakness in his extremities five months after pegylated interferon α (IFNα)-2b was administered. The serum tumor necrosis factor-α (TNFα) was elevated and nerve conduction studies revealed demyelination both in the distal and intermediate segments. The sural nerve pathology showed mild demyelinating process. The cessation of IFNα and administration of intravenous immunoglobulin improved both his clinical symptoms and the temporal dispersion in motor nerve conduction study. IFNα-induced CIDP is presumably a transient immunological condition that requires immunomodulatory therapy. The elevated serum TNFα may implicate the degree of downstream autoimmunitiy induced by IFNα.<br>

Journal

  • Internal Medicine

    Internal Medicine 51 (2), 217-221, 2012

    The Japanese Society of Internal Medicine

Citations (1)*help

See more

References(15)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top