A Case of Follicular Lymphoma Associated with Paraneoplastic Cerebellar Degeneration
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- Shimazu Yayoi
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Minakawa Eiko N.
- Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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- Nishikori Momoko
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Ihara Masafumi
- Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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- Hashi Yuichiro
- Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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- Matsuyama Hirofumi
- Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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- Hishizawa Masakatsu
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Yoshida Sonoyo
- Takashima General Hospital, Japan
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- Kitano Toshiyuki
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Kondo Tadakazu
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Ishikawa Takayuki
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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- Takahashi Ryosuke
- Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
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- Takaori-Kondo Akifumi
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
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Abstract
Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned out to be paraneoplastic cerebellar degeneration, a subtype of PND that develops cerebellar symptoms, that was caused by follicular lymphoma. After chemotherapy, the patient attained sufficient improvement of cerebellar symptoms along with complete remission of lymphoma. Paraneoplastic cerebellar degeneration should be recognized as a rare complication of lymphoma as it is important to start proper treatment before the neurological symptoms become irreversible.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (11), 1387-1392, 2012
The Japanese Society of Internal Medicine
