A Case of Combined Sarcoidosis and Usual Interstitial Pneumonia
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- Tachibana Kazunobu
- Department of Diffuse Lung Diseases and Respiratory Failure, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Arai Toru
- Department of Diffuse Lung Diseases and Respiratory Failure, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Kagawa Tomoko
- Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Minomo Shojiro
- Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Akira Masanori
- Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Kitaichi Masanori
- Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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- Inoue Yoshikazu
- Department of Diffuse Lung Diseases and Respiratory Failure, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Abstract
Sarcoidosis is a systemic granulomatous disease of unknown etiology with characteristic pulmonary lesions, which are often distributed in the upper lung fields. We describe a unique case of sarcoidosis with lower lung field-dominant reticular shadows. Three years after the diagnosis of sarcoidosis based on histologic findings of the mediastinal lymph nodes and transbronchial lung biopsy specimens, the patient developed acute respiratory failure and died. The autopsy showed usual interstitial pneumonia (UIP), with honeycombing and superimposed diffuse alveolar damage of the lungs. The findings suggest that the patient had both sarcoidosis and UIP, and that the UIP later progressed to acute exacerbation.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (14), 1893-1897, 2012
The Japanese Society of Internal Medicine