Long-term Branched-chain Amino Acid Supplementation Improves Glucose Tolerance in Patients with Nonalcoholic Steatohepatitis-related Cirrhosis
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- Miyake Teruki
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Abe Masanori
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Furukawa Shinya
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Tokumoto Yoshio
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Toshimitsu Kumiko
- Nutrition Division, Ehime University Hospital, Japan
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- Ueda Teruhisa
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Yamamoto Shin
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Hirooka Masashi
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Kumagi Teru
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Hiasa Yoichi
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Matsuura Bunzo
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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- Onji Morikazu
- Department of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan
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Abstract
Branched-chain amino acid (BCAA) supplements have mainly been administered as a nutritional intervention for decompensated liver cirrhosis. Several studies have shown that short-term BCAA supplementation improves insulin and glucose tolerance in patients with liver cirrhosis. However, the long-term effects of BCAA supplementation on glucose tolerance and in patients with nonalcoholic steatohepatitis (NASH)-related liver cirrhosis are unknown. Herein, we report 2 cases of NASH-related liver cirrhosis in which long-term BCAA supplementation improved glycemic control. We conclude that in the absence of an effective conventional therapy for NASH-related liver cirrhosis, BCAA supplementation should be considered as an alternative treatment.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (16), 2151-2155, 2012
The Japanese Society of Internal Medicine
