Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity
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- Kitada Mari
- Department of Neurology, Kinki University School of Medicine, Japan
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- Suzuki Hidekazu
- Department of Neurology, Kinki University School of Medicine, Japan
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- Ichihashi Juri
- Department of Neurology, Kinki University School of Medicine, Japan
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- Inada Rino
- Department of Neurology, Kinki University School of Medicine, Japan
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- Miyamoto Katsuichi
- Department of Neurology, Kinki University School of Medicine, Japan
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- Takahashi Toshiyuki
- Department of Neurology, Tohoku University Graduate School of Medicine, Japan
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- Mitsui Yoshiyuki
- Department of Neurology, Kinki University School of Medicine, Japan
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- Fujihara Kazuo
- Department of Neurology, Tohoku University Graduate School of Medicine, Japan
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- Kusunoki Susumu
- Department of Neurology, Kinki University School of Medicine, Japan
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Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (17), 2443-2447, 2012
The Japanese Society of Internal Medicine
