Sarcoidosis Manifesting as Cardiac Sarcoidosis and Massive Splenomegaly

• Kawano Sayaka

  Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan

• Kato Johji

  Frontier Science Research Center, University of Miyazaki, Japan

• Kawano Noriaki

  Department of Internal medicine, Miyazaki Prefectural Hospital, Japan

• Yoshimura Yuki

  Department of Cardiology, Miyazaki Prefectural Hospital, Japan

• Masuyama Hiroyuki

  Department of Cardiology, Miyazaki Prefectural Hospital, Japan

• Fukunaga Takashi

  Department of Cardiology, Miyazaki Prefectural Hospital, Japan

• Shimao Yoshiya

  Department of Pathology, Miyazaki Prefectural Hospital, Japan

• Mihara Kenroh

  Clinical Laboratory, Miyazaki Prefectural Hospital, Japan

• Ueda Akira

  Department of Internal medicine, Miyazaki Prefectural Hospital, Japan

• Toyoda Kiyokazu

  Department of Surgery, Miyazaki Prefectural Hospital, Japan

• Imamura Takuroh

  Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan

• Kitamura Kazuo

  Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan

Abstract

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. We report an unusual case of sarcoidosis in a woman presenting with cardiac sarcoidosis and massive splenomegaly with a familial history of cardiac sarcoidosis. Cardiac sarcoidosis was diagnosed based on electrocardiogram, echocardiogram, ¹⁸F-fluoro-2-deoxyglucose positron emission tomography (¹⁸F-FDG-PET) and skin histological findings. We performed splenectomy to rule out malignant lymphoma, and histological findings confirmed sarcoidosis. After splenectomy, we initiated prednisolone therapy. After 20 months of diagnosis, she was symptom free. Echocardiography and ¹⁸F-FDG-PET may be a key diagnostic tool and prednisolone therapy may be safe, effective, and feasible for cardiac sarcoidosis.<br>

Journal

• Internal Medicine

  Internal Medicine 51 (1), 65-69, 2012

  The Japanese Society of Internal Medicine

Keywords

• cardiac sarcoidosis
• massive splenomegaly
• pacemaker
• splenectomy
• prednisolone

Details

• CRID: 1390001204871705088
• NII Article ID: 130002062410
• DOI: 10.2169/internalmedicine.51.5247
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/51/1/51_1_65/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013012144
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed