Slowly Progressive Insulin-Dependent Diabetes in a Patient with Primary Biliary Cirrhosis with Portal Hypertension-Type Progression

DOI IR Web Site 14 References
  • Takeshita Yumie
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Takamura Toshinari
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Inoue Oto
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Okumura Miki
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Kato Kenichiro
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Sunagozaka Hajime
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Arai Kuniaki
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Misu Hirofumi
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan
  • Nakamura Minoru
    National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biochemical Sciences, Japan
  • Nakanuma Yasuni
    Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Japan
  • Kaneko Shuichi
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Japan

Search this article

Abstract

A 73-year-old woman had previously been diagnosed with CREST syndrome, PBC and diabetes. Hepatic fibrosis was not evident, in spite of the transudative ascites and active esophageal varices. ACA were positive, whereas AMA and anti-gp210 antibodies were negative. She showed low urinary excretion of C-peptide and was weakly positive for anti-GAD antibody. She was diagnosed with a form of PBC that progresses via portal hypertension rather than liver failure and with SPIDDM. Her HLA type did not contain risk allele for IDDM or PBC. SPIDDM should be considered when patients with PBC with portal hypertension-type progression develop diabetes.<br>

Journal

  • Internal Medicine

    Internal Medicine 51 (1), 79-82, 2012

    The Japanese Society of Internal Medicine

References(14)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top