An Elderly Patient with Diabetic Nephropathy Complicated by ANCA-associated Nephritis

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Author(s)

    • Nishino Tomoya
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    • Minami Kana
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    • Uramatsu Tadashi
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan|Division of Blood Purification, Nagasaki University Hospital, Japan
    • Obata Yoko
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan|Career Development Center for Medical Doctor, Nagasaki University Hospital, Japan
    • Arai Hideyuki
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    • Sakamoto Noriho
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    • Taguchi Takashi
    • Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    • Kohno Shigeru
    • The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan

Abstract

A 67-year-old man, on oral therapy for type 2 diabetes mellitus since 1990, had sustained proteinuria since 2005. When hematuria was first discovered in 2008, renal dysfunction [creatinine (Cr), 1.2 mg/dL], inflammation [C-reactive protein (CRP), 12 mg/dL] and high myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) levels [546 ELISA units (EU)] were observed. Renal biopsy showed the diagnosis of ANCA-associated nephritis combined with diabetic nephropathy. For this patient, there was pathological proof of the combination of diabetic nephropathy and ANCA-associated vasculitis.<br>

Journal

  • Internal Medicine

    Internal Medicine 51(10), 1227-1232, 2012

    The Japanese Society of Internal Medicine

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