Evaluation of Mechanical and Biodegradable Properties on Composite Scaffolds Composed of Three-Dimensional Fabric Structure
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- HIWA Chiaki
- Organ. Adv. Sci. Tech., Kobe Univ.
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- YOKOTA Kumiko
- Graduate School of Eng. Kobe Univ.
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- NAKAI Yoshikazu
- Graduate School of Eng. Kobe Univ.
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- TANAKA Nobuo
- Imoto Macinery Co., LTD.
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- IMOTO Toshiyuki
- Imoto Macinery Co., LTD.
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- ADACHI Taiji
- Dept. of Mech. Eng. and Sci., Kyoto Univ.
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- HOJO Masaki
- Dept. of Mech. Eng. and Sci., Kyoto Univ.
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- BABA Shunsuke
- Insti. of Biomed. Res. and Innova., Foundation for Biomed. Res. and Innova.
Bibliographic Information
- Other Title
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- 3次元編み構造からなる生分解性複合材料スカフォールドの力学的特性と生分解性特性の評価
- 3ジゲン アミ コウゾウ カラ ナル セイブンカイセイ フクゴウ ザイリョウ スカフォールド ノ リキガクテキ トクセイ ト セイブンカイセイ トクセイ ノ ヒョウカ
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Abstract
In the aim of tissue regeneration of an alveolar bone, we developed three-dimensional fabric structural composite scaffolds using a bioabsorbable polymer. This scaffold consists of a polylactic acid (PLLA) resin fiber and a 75/25 poly L-lactide-co-glycolide (PLGA) copolymer resin coat. Scaffold is woven on a new-type of three-dimensional loom, has high porosity (89%) and continuous hole. The compressive rigidity and collapse strength of scaffold are increased due to the resin bonding between fiber intersections. The strength of scaffold that did a dip to phosphoric acid buffer solution (PBS) decreased in half due to the hydrolysis in six weeks. Mouse osteoblast-like cells (MC3T3-E1) were seeded onto the scaffolds and cultured in vitro for six weeks. The cells proliferated during in culture and formed a space-filling tissue between polymer fibers. Bone regenerative messenger ALP/DNA levels remained high compared with those one of culture dish. Mineralization of the deposited collagen on scaffold was initially observed at four weeks. Culture of cell on scaffold constructs for six weeks led to formation of a bone tissue.
Journal
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- Journal of the Society of Materials Science, Japan
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Journal of the Society of Materials Science, Japan 57 (9), 868-874, 2008
The Society of Materials Science, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282680394184704
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- NII Article ID
- 130002085620
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- NII Book ID
- AN00096175
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- ISSN
- 18807488
- 05145163
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- NDL BIB ID
- 9653840
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed