Biocompatibility Evaluation of Piezoelectric Materials through Cytotoxicity Test

• UETSUJI Yasutomo

  Dept. of Mech. Eng., Osaka Inst. of Tech.

• UEDA Takahiro

  Dept. of Mech. Eng., Osaka Inst. of Tech.

• HWANG Hwishim

  Graduate School of Eng., Osaka Inst. of Tech.

• HIRANO Yoshiaki

  Dept. of Appl. Chem., Osaka Inst. of Tech.

• TSUCHIYA Kazuyoshi

  Dept. of Precision Eng., Tokai Univ.

• NAKAMACHI Eiji

  Dept. of Biomedical Eng., Doshisha Univ.

Bibliographic Information

Other Title

• 細胞毒性実験による圧電材料の生体適合性評価
• サイボウ ドクセイ ジッケン ニ ヨル アツデン ザイリョウ ノ セイタイ テキゴウセイ ヒョウカ

Abstract

Biocompatible piezoelectric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite-type oxides MgSiO₃, CaSiO₃ and CaTiO₃ of biocompatible piezoelectric materials discovered by first-principles calculation in our previous studies. In order to verify their biocompatibility, the cytotoxicity of similar oxides with the same components was examined as comparing with typical perovskite-type oxides Pb(Zr, Ti)O₃ and BaTiO₃. The fibroblast (L929) cells were cultured during 7days and the effect of materials was evaluated by relative proliferation ratio and doubling time. As a result, it was recognized that MgSiO₃ and CaTiO₃ has the higher biocompatibility. On the other hand, CaSiO₃ and Pb(Zr, Ti)O₃ shows the strong toxicity and they can't be applied to medical devices.

Journal

• Journal of the Society of Materials Science, Japan

  Journal of the Society of Materials Science, Japan 57 (9), 899-904, 2008

  The Society of Materials Science, Japan

Keywords

• Biomaterial
• Piezoelectric Material
• Perovskite-type Oxides
• Cytotoxicity
• Biocompatibility

Details

• CRID: 1390282680394174720
• NII Article ID: 130002085625
• NII Book ID: AN00096175
• DOI: 10.2472/jsms.57.899
• ISSN: 18807488
• ISSN: 05145163
• NDL BIB ID: 9653911
• Web Site: http://id.ndl.go.jp/bib/9653911
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9653911
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed