Development of IVV method into drug discovery

• Yanagawa Hiroshi

  Faculty of Science and Technology, Keio University

Bibliographic Information

Other Title

• プロテインエンジニアリングを利用した次世代バイオ創薬　　ＩＶＶ法のバイオ創薬への展開
• IVV法のバイオ創薬への展開
• IVVホウ ノ バイオソウヤク エ ノ テンカイ

Abstract

We have originally developed the so-called in vitro virus (IVV) method as a more stable and efficient tool for analyzing protein functions. The IVV method is applicable for analyzing and screening protein-protein interactions, transcription factors, RNA binding proteins, bioactive peptides, drug-target proteins, and antibodies using protein, DNA, RNA, drug and antigen as baits, and a randomly primed cDNA library. We further developed a large-scale and high-throughput IVV screening system utilizing a biorobot and microfludic chip.

Journal

• Drug Delivery System

  Drug Delivery System 26 (6), 571-583, 2011

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Keywords

• IVV method
• C-terminal labeling method
• puromycin technology
• mRNA display

Details

• CRID: 1390282679617534848
• NII Article ID: 130002100329
• NII Book ID: AN10084591
• DOI: 10.2745/dds.26.571
• ISSN: 18812732
• ISSN: 09135006
• NDL BIB ID: 023448980
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023448980
• Web Site: https://search.jamas.or.jp/link/ui/2012089293
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed