Suppression of Th2 Response through Breast-feeding in Rats

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  • Kizu Kumiko
    Department of Food and Nutrition, Kyoto Women’s University
  • Hirose Junko
    Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture
  • Honjoh Tsutomu
    Morinaga Institute of Biological Science Inc.
  • Narita Hiroshi
    Department of Food and Nutrition, Kyoto Women’s University

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Other Title
  • 母乳哺育により母ラットの摂取タンパク質特異的に仔ラットのTh2応答が抑制される
  • ボニュウホイク ニ ヨリ ハハ ラット ノ セッシュ タンパクシツ トクイテキ ニ シラット ノ Th2 オウトウ ガ ヨクセイ サレル

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Abstract

Rats were divided into two groups; group E, fed only egg white protein, and group M, fed only cow’s milk protein as a dietary protein source. Immune complexes of the respective dietary proteins and sIgA were found in the breast milk obtained from each group of mothers. When pups fed their own mother’s milk were immunized with egg white protein, serum concentrations of anti-ovomucoid and anti-ovalbumin IgG1 were lower in E-pups than in M-pups. When the pups were immunized with cow’s milk protein in turn, the serum concentration of anti-casein IgG1 was lower in M-pups than in E-pups. Thus, suppression of the Th2 response to dietary protein was acquired via breast-feeding from mothers fed the relevant proteins, probably through the immune complexes of dietary proteins and sIgA secreted into breast milk. The acquired Th2-suppression to egg white protein diminished spontaneously after weaning while the pups were not fed egg white protein.

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