Significance of Delayed Gadolinium Enhancement Cardiac Magnetic Resonance in Patients with Brugada Syndrome
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- Murakami Masato
- Department of Cardiology, Shonan Kamakura General Hospital
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- Nagase Satoshi
- Department of Cardiovascular Medicine, Okayama University
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- Morita Hiroshi
- Department of Cardiovascular Medicine, Okayama University
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- Kusano Kengo
- Department of Cardiovascular Medicine, Okayama University
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- Suenaga Hidetaka
- Department of Cardiology, Shonan Kamakura General Hospital
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- Ito Hiroshi
- Department of Cardiovascular Medicine, Okayama University
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- Saito Shigeru
- Department of Cardiology, Shonan Kamakura General Hospital
抄録
Introduction: Gadlinium-enhanced Cardiac magnetic resonance (CMR) is a useful diagnostic tool for evaluating myocardial abnormality. However, the prevalence of delyed Gadlinium enhancement (DGE) in CMR has not been yet reported in patients with Brugada syndrome (BrS). Methods and Results: Seventy consecutive patients with BrS who underwent Gadlinium-enhanced CMR were evaluated in this study. DGE was found in five patients (7.1%). All patients with DGE were symptomatic. Early repolarization (ER) in inferolateral leads was significantly highly detected in patients with DGE than without DGE (80.0% vs 16.9%, P<0.01). Late potentials examined with SAECG were present in all patients with DGE and in 42 of 65 patients without DGE (64.6%). The value of RMS40 evaluated with SAECG was significantly smaller in patients with DGE than in patients without DGE (p<0.0001). In electrophysiologic study, VF was induced with programmed ventricular stimulation in four of five patients with DGE (80.0%) and in 21 of 41 patients without DGE (51.2%). Mutation analysis revealed that DGE was present in one patient with SCN5A mutation and in 2 patients without SCN5A mutation. Conclusions: Depolarization abnormality is prominent in BrS patients with DGE. CMR with DGE might be a useful tool for evaluating high risk patient with BrS.
収録刊行物
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- Journal of Arrhythmia
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Journal of Arrhythmia 27 (Supplement), OP36_2-, 2011
日本不整脈学会
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詳細情報 詳細情報について
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- CRID
- 1390282680221769984
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- NII論文ID
- 130002129943
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- ISSN
- 18832148
- 18804276
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可