リアルタイム生体内共焦点レーザ顕微鏡を用いた drug delivery systems(DDS)の動態評価法  [in Japanese] Evaluation of the Dynamics of Drug Delivery Systems (DDS) Using Intravital Real-Time Confocal Laser Scanning Microscopy  [in Japanese]

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Author(s)

Abstract

  The concept of drug delivery systems (DDS) promises the treatments for the refractory diseases such as cancer. Many kinds of multifunctional DDS have been developed, demonstrating enhanced drug accumulation and therapeutic efficiency. However, it is quite difficult to evaluate that the DDS really perform as expected under <i>in vivo</i> conditions. We have recently developed the intravital real-time confocal laser scanning microscopy (IVRTCLSM) characterized by rapid scanning and simultaneous multicolor detection, to visualize the behavior of DDS in living mice. IVRTCLSM revealed the dynamic states of DDS, which could not be observed by conventional <i>in vitro</i>/<i>ex vivo</i> methods, in the bloodstream, tumors, and other organs. IVRTCLSM will provide new facets in the DDS study, and will facilitate the development of DDS.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 132(12), 1347-1354, 2012

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130002489530
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    024129186
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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