A Multicenter Study on the Prevalence of Eosinophilic Esophagitis and PPI-Responsive Esophageal Eosinophilic Infiltration
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- Fujiwara Yasuhiro
- Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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- Sugawa Takashi
- Department of Gastroenterology, Osaka Hospital of Japanese Seafarers Relief Association, Japan
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- Tanaka Fumio
- Department of Gastroenterology, Izumiotsu Municipal Hospital, Japan
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- Tatsuwaki Hiroshi
- Department of Internal Medicine, Yamamoto Third Hospital, Japan
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- Okuyama Masatsugu
- Department of Gastroenterology, Kashiwara Municipal Hospital, Japan
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- Hayakawa Tsuyoshi
- Department of Gastroenterology, Imazato Gastrointestinal Hospital, Japan
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- Yamamori Kazuki
- Department of Gastroenterology, Osaka Hospital of Japanese Seafarers Relief Association, Japan
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- Wada Rikimon
- Department of Gastroenterology, Asakayama General Hospital, Japan
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- Ohtani Kenjiro
- Department of Gastroenterology, Nagayoshi General Hospital, Japan
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- Uno Hironori
- Department of Gastroenterology, Ohno Memorial Hospital, Japan
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- Tanigawa Tetsuya
- Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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- Watanabe Yoshihisa
- Department of Gastroenterology, Asakayama General Hospital, Japan
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- Tominaga Kazunari
- Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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- Watanabe Toshio
- Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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- Takaishi Osamu
- Department of Gastroenterology, Kashiwara Municipal Hospital, Japan
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- Saeki Yoshihiko
- Department of Gastroenterology, Imazato Gastrointestinal Hospital, Japan
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- Nebiki Hiroko
- Department of Gastroenterology, Osaka City General Hospital, Japan
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- Oshitani Nobuhide
- Department of Gastroenterology, Izumiotsu Municipal Hospital, Japan
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- Sato Hiroshi
- Department of Gastroenterology, Osaka City General Hospital, Japan
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- Arakawa Tetsuo
- Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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Abstract
Objective Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of ≥15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study.<br> Methods Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of ≥15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI.<br> Results A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI.<br> Conclusion EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (23), 3235-3239, 2012
The Japanese Society of Internal Medicine