腎での尿酸排泄亢進とオキシプリン排泄低下を示した低尿酸・高オキシプリン血症の1例
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- タイトル別名
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- A case of renal hypouricemia associated with increased plasma oxypurine concentration due to its decreased excretion
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We report a case of decreased urate and increased oxypurine concentrations in plasma due to impaired renal handling of these purines. The patient was a 50-year-old man suffering from Parkinsonism. His serum urate concentration was low (0.98±0.02mg/dl [58.3±1.2μmol/l ]; Mean ± S. E. ), but renal urate clearance and percentage of urate clearance to creatinine clearance were high (30.3 ±1.6ml/min and 31.4±1.2%, respectively), and were not affected by pyrazinamide or probenecid loading. These findings indicated that hypouricemia in this case was caused by impaired tubular reabsorption of urate. On the other hand, his plasma oxypurine concentrations were elevated (hypoxanthine 5.90±1.55μmol/l vs. normal controls 1.72±0.08; xanthine 1.32±0.05 vs.0.49±0.02), and plasma inosine level was also high (2.52±0.29 vs.0.41±0.05). The xanthine oxidase activity and oxypurine concentration in the liver were normal. We studied the renal clearance of oxypurine and inosine in this patient. His renal clearance of oxypurine was about 50% of normal controls (CHX/Ccr 11.8±1.1% vs.25.0±1.6; CX/Ccr 25.5±2.6 vs.46.5±2.4). Clearance of inosine (CIno/Ccr) was also reduced to 25% of normal controls (7.2±0.5 vs.29.4±5.9). These results suggested that increased plasma concentration of oxypurine in this patient was due to the decreased renal excre tion of oxypurine.
収録刊行物
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- Purine and pyrimidine metabolism
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Purine and pyrimidine metabolism 13 (1), 1-6, 1989
一般社団法人 日本痛風・核酸代謝学会
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詳細情報 詳細情報について
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- CRID
- 1390001204768483840
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- NII論文ID
- 130003356403
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- ISSN
- 21870101
- 09162836
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可