Synthesis of 2,3-Bis(halomethyl)quinoxaline Derivatives and Evaluation of Their Antibacterial and Antifungal Activities

• Ishikawa Hisato

  Department of Materials and Life Science, Faculty of Science and Technology, Seikei University

• Sugiyama Takayuki

  Japan EnviroChemicals, Ltd.

• Yokoyama Akihiro

  Department of Materials and Life Science, Faculty of Science and Technology, Seikei University

Abstract

Quinoxaline derivatives having bis(fluoromethyl), bis(chloromethyl), or bis(iodomethyl) groups at the 2- and 3-positions, and various electron-donating/withdrawing substituents at the 6- and/or 7-positions, were synthesized. Their antibacterial and antifungal activities were evaluated by means of minimum inhibitory concentration assays. The relationships between the substituents and the antimicrobial activities of the quinoxaline derivatives indicate that the electrophilicity of the halomethyl units plays an important role in generating the antimicrobial activity.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 61 (4), 438-444, 2013

  The Pharmaceutical Society of Japan

Keywords

• quinoxaline
• antibacterial activity
• antifungal activity
• halomethyl

Details

• CRID: 1390001204176713088
• NII Article ID: 130003360754
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c12-01061
• COI: 1:STN:280:DC%2BC3srhtlOlug%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 024369399
• PubMed: 23546003
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024369399
• Web Site: https://www.jstage.jst.go.jp/article/cpb/61/4/61_c12-01061/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed