Concise Synthesis of Heterocycle-Fused Naphthoquinones by Employing Sonogashira Coupling and Tandem Addition-Elimination/Intramolecular Cyclization
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A concise method for the synthesis of heterocycle-fused naphthoquinones such as naphtho[2,3-<i>b</i>]-furan-4,9-dione, 1<i>H</i>-benz[<i>f</i>]indole-4,9-dione, and naphtho[2,3-<i>b</i>]thiophene-4,9-dione was developed. This method employed Sonogashira coupling and tandem addition-elimination/intramolecular cyclization, and it enabled the preparation of versatile heterocycle-fused naphthoquinones from one substrate.
- Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin 61(6), 648-654, 2013
The Pharmaceutical Society of Japan