Synthesis of VIP-Lipopeptide Using a New Linker to Modify Liposomes: Towards the Development of a Drug Delivery System for Active Targeting

Access this Article

Author(s)

Abstract

A new component for the solid phase peptide synthesis of lipopeptide, 2-[(4<i>R</i>,5<i>R</i>)-5-({[(9<i>H</i>-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid (<b>2</b>), was designed and synthesized from (−)-2,3-<i>O</i>-isopropylidene-<span style="font-variant: small-caps;">D</span>-threitol (<b>3</b>) in 4 steps. The key step was the selective alkylation of <b>3</b> with benzyl bromoacetate in the presence of Cs<sub>2</sub>CO<sub>3</sub>. Vasoactive intestinal peptide (VIP)-lipopeptide (<b>1</b>) incorporating this linker was synthesized by solid phase peptide synthesis.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 61(11), 1184-1187, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003360912
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • NDL Article ID
    024957254
  • NDL Call No.
    Z53-D167
  • Data Source
    NDL  J-STAGE 
Page Top