Dynamic Modeling of Metabolic and Gene Regulatory Systems toward Developing Virtual Microbes

• Kurata Hiroyuki

  Department of Bioscience and Bioinformatics, Kyushu Institute of Technology Biomedical Informatics R&D Center, Kyushu Institute of Technology

• Maeda Kazuhiro

  Department of Bioscience and Bioinformatics, Kyushu Institute of Technology

• Matsuoka Yu

  Department of Bioscience and Bioinformatics, Kyushu Institute of Technology

抄録

In systems biology, computer simulation of the biochemical networks of a microbial cell is a powerful method to predict their function and phenotype under different culture conditions and genetic modifications. Construction of a virtual microbe, a generic mathematical model of cell growth and metabolism, can be an ambitious but realistic project. It would enable the rational design of a biochemical network to enhance the production of useful metabolites and proteins. However, there exist critical problems, such as parameter uncertainty, mechanism complexity and high dimensionality of the model. We would like to review the dynamic models of the biochemical networks with their problems, providing insight into developing a virtual microbe.

収録刊行物

• JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

  JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 47 (1), 1-9, 2014

  公益社団法人 化学工学会

キーワード

• Dynamic Models
• Biochemical Network
• Computer Simulation
• Design

詳細情報

• CRID: 1390282679544726016
• NII論文ID: 130003361309
• NII論文ID: 40020026643
• NII書誌ID: AA00709658
• DOI: 10.1252/jcej.13we152
• ISSN: 18811299
• ISSN: 00219592
• NDL書誌ID: 025362826
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025362826
• Web Site: https://www.jstage.jst.go.jp/article/jcej/47/1/47_13we152/_pdf
• 本文言語コード: en
• データソース種別:
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