Electrophysiological and Pharmacological Properties of the Pulmonary Vein Myocardium

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Author(s)

Abstract

The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species have revealed characteristics such as presence of intracellular Ca<sup>2+</sup> oscillations and low repolarizing potency. The automaticity of the pulmonary vein myocardium is affected by various neurotransmitters, hormones and pharmacological agents. Clarification of the mechanisms and regulation of pulmonary vein automaticity would lead to the development of novel therapeutic strategies and pharmacological agents for atrial fibrillation.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 36(1), 2-7, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003361359
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • NDL Article ID
    024173295
  • NDL Call No.
    Z53-V41
  • Data Source
    NDL  J-STAGE 
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