Non-genomic Action of Sex Steroid Hormones and Cardiac Repolarization

DOI Web Site Web Site PubMed 被引用文献2件 参考文献33件
  • Kurokawa Junko
    Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
  • Furukawa Tetsushi
    Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

この論文をさがす

抄録

Gender differences play a major role in the manifestation of cardiovascular disease including cardiac arrhythmias. In particular, female sex is an independent risk factor for development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes but also in acquired long QT syndromes which occur as adverse effects of existing drugs. Recent clinical and experimental studies suggest that the gender differences may stem, at least in part, from gender differences in cardiac repolarization process, that is longer rate-corrected QT (QTC) interval in women than in men. In women, QTC interval and arrhythmic risks in TdP alter cyclically during menstrual cycle, suggesting a critical role of female sex hormones in cardiac repolarization process. These gender differences in fundamental cardiac electrophysiology result from variable ion channel expression and diverse sex hormonal regulation via long term genomic and acute non-genomic pathways, and sex differences in drug responses and metabolisms. In particular, non-genomic actions of testosterone and progesterone on cardiac ion channels likely to contribute to the gender differences in cardiac repolarization processes.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (33)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ