ナノ粒子設計に基づく機能性 <sup>1</sup>H MRIプローブの開発

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  • 水上 進
    大阪大学大学院工学研究科 大阪大学免疫学フロンティア研究センター

書誌事項

タイトル別名
  • Development of Functional <sup>1</sup>H MRI Probes Based on Nanoparticle Design
  • ナノ粒子設計に基づく機能性¹H MRIプローブの開発
  • ナノ リュウシ セッケイ ニ モトズク キノウセイ ¹ H MRI プローブ ノ カイハツ

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抄録

  Visualization of biomolecules in living bodies has attracted increasing attention in recent years. Magnetic resonance imaging (MRI) is a noninvasive technique that yields high-resolution structural information of deep anatomical regions; therefore, it has promising applications in the development of probes to visualize biological functions. By using stimuli-responsive polymers, we developed 1H MRI probes to measure the pH of aqueous solutions. The longitudinal relaxivity of P-Gd, a conjugate of n-octylamine-modified poly(SM-EVE) with Gd3+ complexes, increased as the pH of the solution decreased from neutral to acidic. Fluorometric investigation confirmed that the side chains of P-Gd were more rotationally restricted in acidic pH than in neutral pH conditions. In order to improve the magnitude of relaxivity, we developed novel probes C10-Gd and C30-Gd on the basis of cross-linked polymer nanoparticles. The relaxivities of these probes were measured, and the values showed that these nanoparticle-based probes also possessed pH-responsive molecular switches. In addition, their relaxivities were much larger than those of non-cross-linked probes. These nanoparticle-based MRI probes would be useful for the diagnosis of various diseases such as cancer and inflammatory diseases.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 133 (3), 351-354, 2013-03-01

    公益社団法人 日本薬学会

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