全身レベルの免疫細胞動態可視化による免疫系の理解  [in Japanese] Understanding of Immune System by Visualization of Spatiotemporal Regulation of Immune Cells in the Entire Body  [in Japanese]

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Author(s)

    • 戸村 道夫 Tomura Michio
    • 京都大学医学研究科次世代免疫制御を目指す創薬医学融合拠点 Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine

Abstract

  Immune system is high-dimensional integrated system distributed in the whole body. Many kinds of, total 10<sup>11</sup> of immune cells are regulated by receiving appropriate signals in appropriate places. We have been attempting to understand immune system by revealing spatiotemporal regulation of immune cells at the whole body level by “Visualization of immune response <i>in vivo</i>”. Photoconvertible protein, “Kaede”-Tg mice allowed us to monitor cell-replacement and cell-movement in the whole body by marking cells with color of Kaede from green to red with exposure to violet light. It is applicable to small cell number populations in both lymphoid organs and also peripheral tissues under both normal and pathophysiological conditions. By using this system, we have demonstrated novel findings that “Naive CD4<sup>+</sup> T cell recirculation is an active process that they recirculate through lymphoid organs to seek limited niche for interacting with endogenous antigens and upregulate their function.” and “Activated regulatory T cells emigrating from cutaneous immune response is responsible for termination of immune reponse.” I will introduce these new tools of us and would like to discuss what is needed to understand immune system in the entire body.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133(4), 427-433, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003361934
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    024608473
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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