Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein

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Author(s)

    • Hara Tomoya
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Ueda Yuka
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Tomita Noriko
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Taketani Yoshio
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Yamada Hirotsugu
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Soeki Takeshi
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Wakatsuki Tetsuzo
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Sata Masataka
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Yamaguchi Koji
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Iwase Takashi
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Kadota Muneyuki
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Bando Mika
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Ogasawara Kozue
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Bando Sachiko
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Ise Takayuki
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Niki Toshiyuki
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School

Abstract

A 67-year-old woman with asthma visited our hospital with increasing dyspnea and new-onset paresthesia and purpura in her legs. Physical examination showed a wheeze, pretibial edema, and surrounding purpura. Chest X-rays showed cardiac decompensation and an electrocardiogram revealed a new ST-T change. Laboratory data showed leukocytosis, hypereosinophilia (10,450/<I>μ</I>L), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> 150 ng/mL). Echocardiography revealed diffuse left ventricular hypokinesis (ejection fraction 30%) with increased wall thickness. Coronary angiography was normal. Cardiac magnetic resonance imaging implied diffuse myocardial edema and subendocardial late gadolinium enhancement. Skin biopsy of purpura showed superfi cial perivascular dermatitis with remarkable eosinophilic infiltrations. No evidence of drug allergies, parasitic infection, or myeloproliferative disorder was detected. Based on these findings, a diagnosis of eosinophilic myocarditis due to Churg-Strauss syndrome was considered. She was administered prednisolone at a dose of 1 mg/kg, cyclophosphamide, and diuretics. Several markers of eosinophilic myocarditis and heart failure gradually improved, including ECP. She was discharged 30 days later with no cardiac event. Eosinophilic myocarditis is characterized by predominantly eosinophilic infi ltration. Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. We experienced a rare case of eosinophilic myocarditis due to Churg-Strauss syndrome. Markedly elevated ECP played an important role in the early diagnosis and subsequent reduction in ECP served as a marker of monitoring. In an asthmatic patient with dyspnea, hypereosinophilia, and vasculitis, Churg-Strauss syndrome with eosinophilic myocarditis should be considered.

Journal

  • International Heart Journal

    International Heart Journal 54(1), 51-53, 2013

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130003364440
  • Text Lang
    ENG
  • ISSN
    1349-2365
  • Data Source
    J-STAGE 
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