Environmental Characteristics and Oxidative Stress of Inhabitants and Patients with Amyotrophic Lateral Sclerosis in a High-incidence Area on the Kii Peninsula, Japan

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Author(s)

    • Kihira Tameko
    • Department of Health Sciences, Kansai University of Health Sciences, Japan
    • Kuzuhara Shigeki
    • Department of Neurology, Mie University Graduate School of Medicine, Japan|Department of Medical Welfare, Suzuka University of Medical Science, Japan
    • Yoshida Sohei
    • Department of Health Sciences, Kansai University of Health Sciences, Japan
    • Kondo Tetuya
    • Department of Health Sciences, Kansai University of Health Sciences, Japan
    • Iwai Keiko
    • Faculty of Nursing, Kansai University of Health Sciences, Japan
    • Wada Sachiko
    • Faculty of Nursing, Kansai University of Health Sciences, Japan
    • Kokubo Yasumasa
    • Department of Neurology, Mie University Graduate School of Medicine, Japan

Abstract

<b>Objective</b> Although Oshima, in the Kii Peninsula of Japan, is located within a high incidence area of amyotrophic lateral sclerosis (ALS) (Koza/Kozagawa/Kushimoto area, K area), no patients with ALS were detected between 1960 and 1999. However, the incidence recently increased between 2000 and 2009. On Oshima, the source of drinking water was changed from a regional river/wells to the Kozagawa River in the K area in 1975. We speculate that this change in water source may have played a role in the recent increase in the incidence of ALS. The aim of this study is to find contributing factors that may have triggered the locally high incidence of ALS.<br> <b>Methods</b> We investigated a possible association between the mineral content of drinking water and serum and oxidative stress markers among patients with ALS in the K area (K-ALS), residents of Oshima and controls.<br> <b>Results</b> We found that the levels of Ca and Zn in the recent drinking water in Oshima are low and that the serum levels of Ca and Zn in the Oshima residents and patients with K-ALS were significantly lower, while the oxidative stress markers were significantly higher, than those of the controls. The serum Zn and urinary 8-OHdG/creatinine levels explained 60% and 58% of the variations among the three groups, respectively. The serum Zn levels were negatively correlated with the serum Cu levels in the patients with K-ALS, and the serum Cu levels exhibited a tendency to be positively correlated with the 8-OHdG/creatinine levels in both the patients with K-ALS (r: 0.64) and the residents free from K-ALS (r: 0.32, p<0.01).<br> <b>Conclusion</b> Taken together, we suggest that the low levels of Ca and Zn in the drinking water are possibly associated with an imbalance of metal metabolism in Oshima residents and an increase in oxidative stress markers in patients with K-ALS, although the causative relationship is not clear. This is a cross-sectional study, and a prospective study is needed in the future.<br>

Journal

  • Internal Medicine

    Internal Medicine 52(13), 1479-1486, 2013

    The Japanese Society of Internal Medicine

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