Pulmonary Tumor Thrombotic Microangiopathy with Circulatory Failure Treated with Imatinib
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- Ogawa Aiko
- Department of Clinical Science, National Hospital Organization Okayama Medical Center, Japan
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- Yamadori Ichiro
- Department of Clinical Pathology, National Hospital Organization Okayama Medical Center, Japan
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- Matsubara Osamu
- Department of Pathology, Hiratsuka Kyosai Hospital, Japan
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- Matsubara Hiromi
- Department of Clinical Science, National Hospital Organization Okayama Medical Center, Japan
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Abstract
Pulmonary tumor thrombotic microangiopathy is a lethal, yet difficult to diagnose, complication of gastrointestinal carcinoma. Even if properly diagnosed, there is no treatment, especially after a circulatory collapse. We herein report a case of pulmonary tumor thrombotic microangiopathy with circulatory failure due to pulmonary hypertension. The patient was temporarily successfully treated with imatinib, an inhibitor of the platelet-derived growth factor receptor. Pulmonary hypertension was dramatically ameliorated and the patient was able to be weaned from percutaneous cardiopulmonary support within 20 days of treatment. Imatinib may be effective for ameliorating pulmonary hypertension that is caused by pulmonary tumor thrombotic microangiopathy.<br>
Journal
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- Internal Medicine
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Internal Medicine 52 (17), 1927-1930, 2013
The Japanese Society of Internal Medicine