Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

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Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (<i>CTNNB1</i>). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of <i>CTNNB1</i>. We also present a review of the literature describing the clustering of <i>CTNNB1</i> mutations in patients with SPN.<br>


  • Internal Medicine

    Internal Medicine 52(18), 2051-2056, 2013

    The Japanese Society of Internal Medicine


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