Laser-Perforated Porous Nonwoven Chitosan Nerve Conduit

• RODOTHEOU Petros

  Department of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University

• WANG Wei

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• ITOH Soichiro

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• OKAZAKI Mutsumi

  Department of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University

• TAKAKUDA Kazuo

  Department of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University

抄録

Chitosan nonwoven mesh conduit was introduced with perforating pores on the wall by laser-drilling process. The pore size was set at 200 µm and the pore interval at 1mm. Twelve mm long grafts of following 4 groups (N=5, respectively) were implanted to rat sciatic nerve defects: non-pore, 2 lines of pores, 4 lines of pores and isograft. After 12 weeks standard nerve function evaluations were performed including functional test, electro conductivity test and histological analysis. It was found that revascularization of the conduit contents was improved with pores drilled, but accompanied nerve regenerative improvements were only shown as maturation of fasciculi, not with the general parameters of axon diameter and density.

収録刊行物

• Journal of Biomechanical Science and Engineering

  Journal of Biomechanical Science and Engineering 8 (2), 139-151, 2013

  一般社団法人 日本機械学会

キーワード

• Nerve Regeneration
• Chitosan Conduit
• Laser Perforating
• Nano Scaffold

詳細情報

• CRID: 1390001205261852288
• NII論文ID: 130003366819
• DOI: 10.1299/jbse.8.139
• ISSN: 18809863
• Web Site: https://www.jstage.jst.go.jp/article/jbse/8/2/8_139/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可