Dietary Reference Intakes for Japanese 2010: Fat-Soluble Vitamins

  • TANAKA Kiyoshi
    Department of Food and Nutrition, Kyoto Women's University
  • TERAO Junji
    Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School
  • SHIDOJI Yoshihiro
    Department of Nutrition and Health Science, Graduate School of Human Health Science, University of Nagasaki
  • TAMAI Hiroshi
    Department of Pediatrics, Osaka Medical College
  • IMAI Eri
    Section of the Dietary Reference Intakes, Department of Nutritional Epidemiology, National Institute of Health and Nutrition
  • OKANO Toshio
    Department of Hygienic Sciences, Kobe Pharmaceutical University

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Abstract

We have determined the Dietary Reference Intakes for fat-soluble vitamins (vitamin A, vitamin D, vitamin E, and vitamin K) for the Japanese. Regarding vitamin A, the estimated average requirement (EAR) and the recommended dietary allowance (RDA) were defined for those aged 1 y old and over. For vitamin D, vitamin E, and vitamin K, the EAR or RDA was not adopted, because of the insufficient data available. Thus, the adequate intake (AI) was determined for those vitamins based on the food surveillance data and biomarkers for each vitamin. The AI for vitamin D was decided as the median intake of vitamin D in the population with a circulating 25-hydroxy vitamin D level which was high enough for bone health. The basis for the AI for vitamin E was the median intake of α-tocopherol in the healthy population considering the lack of unfavorable health consequences attributable to its deficiency. The AI for vitamin K was determined as the vitamin K intake, required to avoid blood coagulation abnormalities. The tolerable upper intake level (UL) was determined for vitamin A, vitamin D and vitamin E, but not for vitamin K, since no adverse effects have been reported even with its high dosage.

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