Relationship between Virus-Neutralizing Antibody Levels and the Number of Rabies Vaccinations: a Prospective Study of Dogs in Japan
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- Watanabe Ippei
- Department of Microbiology, Faculty of Medicine, Oita University
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- Yamada Kentaro
- Research Promotion Institute, Oita University
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- Aso Akira
- Oita Veterinary Medical Association
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- Suda Okio
- Suda Veterinary Hospital
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- Matsumoto Takashi
- Department of Microbiology, Faculty of Medicine, Oita University
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- Yahiro Takaaki
- Department of Microbiology, Faculty of Medicine, Oita University
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- Ahmed Kamruddin
- Research Promotion Institute, Oita University
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- Nishizono Akira
- Department of Microbiology, Faculty of Medicine, Oita University
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抄録
A mass rabies vaccination of dogs has been conducted annually in Japan over the last 60 years. To assess both current levels of rabies virus-neutralizing antibody (VNA) in dogs and the rationale for current vaccination procedures, we used a rapid fluorescent focus inhibition test to determine VNA levels in 756 dogs that had visited animal hospitals in Japan. We found that 51.1% of the dogs that had received 1 rabies vaccination had protective VNA levels (≥0.5 IU/ml) with a geometric mean of 0.61 IU/ml. In contrast, 97.8% of the dogs that had been vaccinated at least twice had protective VNA levels with a geometric mean of 7.86 IU/ml. Furthermore, 97.9–100% of the dogs vaccinated at least twice retained protective VNA levels into the second year after the last vaccination. Although VNA levels in the dogs vaccinated at least twice tended to decline 2 years after the last vaccination, 78.9% retained protective VNA levels. Thus, the current rabies vaccination schedule provides adequate protection, but the registration system and vaccination schedule needs to be improved to ensure that increased numbers of dogs are vaccinated against rabies.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 66 (1), 17-21, 2013
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681217837056
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- NII論文ID
- 130003381634
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 024217213
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- PubMed
- 23429079
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可