Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of <i>Dipsacus asper</i>

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Author(s)

Abstract

A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (<b>1</b>), and 20 known compounds (<b>2</b>–<b>21</b>) were isolated from a water extract of <i>Dipsacus asper</i> roots. Compound <b>1</b> possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 61(12), 1318-1322, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003381796
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • NDL Article ID
    025047843
  • NDL Call No.
    Z53-D167
  • Data Source
    NDL  J-STAGE 
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