Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of <i>Dipsacus asper</i>
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A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (<b>1</b>), and 20 known compounds (<b>2</b>–<b>21</b>) were isolated from a water extract of <i>Dipsacus asper</i> roots. Compound <b>1</b> possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.
- Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin 61(12), 1318-1322, 2013
The Pharmaceutical Society of Japan