Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows

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Author(s)

    • NANIWA Yousuke NANIWA Yousuke
    • Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan|Research Fellow of the Japan Society for the Promotion of Science
    • SETSUDA Shohei
    • Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • OISHI Shinya
    • Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • FUJII Nobutaka
    • Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • MATSUDA Fuko
    • Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
    • UENOYAMA Yoshihisa
    • Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
    • TSUKAMURA Hiroko
    • Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
    • MAEDA Kei-ichiro
    • Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan

Abstract

Kisspeptin is a key molecule that stimulates gonadotropin secretion via release of gonadotropin-releasing hormone (GnRH). In the present study, our aim was to investigate whether kisspeptin has stimulatory effects on follicular development via GnRH/gonadotropin secretion in cows. Japanese Black beef cows were intravenously injected with full-length bovine kisspeptin [Kp-53 (0.2 or 2 nmol/kg)] or vehicle 5 days after they exhibited standing estrus (Day 0). In cows injected with Kp-53 at 2 nmol/kg, the follicular sizes of the first dominant follicles increased on Day 6 and thereafter. Ovulation of the first dominant follicle occurred in 1 out of 4 cows treated with Kp-53 at 2 nmol/kg. Injection of Kp-53 at 2 nmol/kg increased the concentration of plasma luteinizing hormone (LH) but not follicle-stimulating hormone, over a 4-h period following injection in all cows. The present study suggests that administration of full-length kisspeptin causes LH secretion, which is sustained for a few hours, and it is capable of stimulating follicular development and/or ovulation.

Journal

  • Journal of Reproduction and Development

    Journal of Reproduction and Development 59(6), 588-594, 2013

    THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

Codes

  • NII Article ID (NAID)
    130003381852
  • NII NACSIS-CAT ID (NCID)
    AA10936678
  • Text Lang
    ENG
  • ISSN
    0916-8818
  • NDL Article ID
    025084340
  • NDL Call No.
    Z54-H305
  • Data Source
    NDL  J-STAGE 
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