Improvement of Reticuline Productivity from Dopamine by Using Engineered <i>Escherichia coli</i>

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  • KIM Ju-Sung
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • NAKAGAWA Akira
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • YAMAZAKI Yuya
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • MATSUMURA Eitaro
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • KOYANAGI Takashi
    Department of Food Science, Ishikawa Prefectural University
  • MINAMI Hiromichi
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • KATAYAMA Takane
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
  • SATO Fumihiko
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University
  • KUMAGAI Hidehiko
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University

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  • Improvement of Reticuline Productivity from Dopamine by Using Engineered Escherichia coli

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Abstract

Benzylisoquinoline alkaloids (BIAs) are pharmaceutically important compounds. We have previously devised a reticuline (BIA) production method from dopamine by using Escherichia coli; however, its productivity was relatively low (33 µM, 11 mg/L). We report here, by fine-tuning the method, higher reticuline productivity of 165 µM (54 mg/L), increasing the conversion efficiency by 8-fold. These results are important for developing an efficient route to fermentative reticuline production.

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