Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of <i>Pleurotus eryngii</i> in Ovariectomized Rats

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  • Minami Akira
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Matsushita Hiroshi
    Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
  • Horii Yuuki
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Ieno Daisuke
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Matsuda Yukino
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Saito Masakazu
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Kanazawa Hiroaki
    Department of Functional Anatomy, School of Nursing, University of Shizuoka
  • Ohyama Yuriko
    Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
  • Wakatsuki Akihiko
    Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
  • Takeda Atsushi
    Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Hidari Kazuya I. P. J.
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
  • Sabaratnam Vikineswary
    Institute of Biological Sciences, Faculty of Science, University of Malaya
  • Suzuki Takashi
    Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka

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  • Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of Pleurotus eryngii in Ovariectomized Rats

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Abstract

Ethanol extract of Pleurotus eryngii (DC.) QUÉL has estrogen-like activities that protect against bone loss caused by estrogen deficiency. In the present study, we investigated the effect of P. eryngii on depression-like behavior and memory impairment in ovariectomized (OVX) rats. Immobility time during a forced swimming test was significantly longer for OVX rats than for sham-operated rats. The depression-like behavior in OVX rats was improved by long-term administration of the ethanol extract of P. eryngii (500 mg/kg body weight (b.w.)/d). Spatial memory impairment in OVX rats assessed by the Morris water maze test was also improved by P. eryngii extract without any effect on motility. These results suggested that P. eryngii extract has estrogen-like improvement activity against depression-like behavior and memory impairment in OVX rats. Additionally, increase in the amount of synaptosomal zinc after ovariectomy was inhibited by P. eryngii extract. Since zinc in synaptic vesicles is important for memory function and is linked to the pathophysiology of depression, normalization of zinc signaling would be involved in the beneficial effect of P. eryngii extract on neurological disorders after ovariectomy.

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