Mast Cell Stabilizing Effect of (-)‐Elema‐1,3,11(13)‐trien‐12‐ol and Thujopsene from Thujopsis dolabrata Is Mediated by Down‐Regulation of Interleukin‐4 Secretion in Antigen‐Induced RBL‐2H3 Cells
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- Kim Chul-Hee
- Natural Products Research Institute, College of Pharmacy, Seoul National University
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- Lee Taehun
- Natural Products Research Institute, College of Pharmacy, Seoul National University
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- Oh Ikhoon
- Natural Products Research Institute, College of Pharmacy, Seoul National University
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- Nam Kung-Woo
- Office of Industrial Cooperation, Soon Chun Hyang University
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- Kim Kyeong Ho
- College of Pharmacy, Kangwon National University
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- Oh Ki-Bong
- School of Agriculture Biotechnology, Seoul National University
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- Shin Jongheon
- Natural Products Research Institute, College of Pharmacy, Seoul National University
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- Mar Woongchon
- Natural Products Research Institute, College of Pharmacy, Seoul National University
書誌事項
- タイトル別名
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- Mast Cell Stabilizing Effect of (−)-Elema-1,3,11(13)-trien-12-ol and Thujopsene from <i>Thujopsis dolabrata</i> Is Mediated by Down-Regulation of Interleukin-4 Secretion in Antigen-Induced RBL-2H3 Cells
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Several isolated compounds from the wood part of Thujopsis dolabrata were evaluated for their inhibitory effects against antigen-induced mast cell degranulation and interleukin-4 (IL-4) secretion, as well as IL-4 mRNA and protein expression in immunoglobulin E (IgE)-sensitized RBL-2H3 cells. Among the five isolated compounds, (−)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) exhibited the potent inhibitory activity against mast cell degranulation measured by β-hexosaminidase release with IC50 values of 27.4 µM and 25.1 µM, respectively. These compounds also inhibited the release of IL-4 (IC50 values of 7.0, 6.7 µM, respectively), IL-4 mRNA expression (IC50 values of 16.5, 7.2 µM, respectively) and IL-4 protein expression (IC50 values of 17.0, 9.6 µM, respectively) in antigen-induced IgE-sensitized RBL-2H3 cells. These results suggested that (−)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) effectively inhibits mast cell degranulation as well as IL-4 production, suggesting that these compounds from Thujopsis dolabrata can be used as candidates for IgE-mediated allergic disorders.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (3), 339-345, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679608790656
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- NII論文ID
- 130003382075
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3svit1yhtA%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024283597
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- PubMed
- 23449323
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可