Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community:– The Hisayama Study –

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Author(s)

    • Izumaru Kensuke Izumaru Kensuke
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Nagata Masaharu [他] Ninomiya Toshiharu
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Nagata Masaharu
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Usui Tomoko
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Yoshida Daigo
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
    • Fukuhara Masayo
    • Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Tsuruya Kazuhiko
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Kitazono Takanari
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

Abstract

<b><i>Background:</i></b> Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. <b><i>Methods and Results:</i></b> A total of 2,417 community-dwelling individuals without CKD stage 3–5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3–5, defined as estimated glomerular filtration rate (eGFR) <60ml·min<sup>−1</sup>·1.73m<sup>−2</sup>, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D), were estimated. During follow-up, 378 subjects experienced CKD stage 3–5. The age- and sex-adjusted incidence of CKD stage 3–5 increased significantly with decreasing serum 1,25(OH)<sub>2</sub>D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3–5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)<sub>2</sub>D was significantly associated with a greater change in eGFR (−0.10ml·min<sup>−1</sup>·1.73m<sup>−2</sup>·year<sup>−1</sup> per 10-pg/ml decrement in serum 1,25(OH)<sub>2</sub>D). <b><i>Conclusions:</i></b> Lower serum 1,25(OH)<sub>2</sub>D is a significant risk factor for the development of CKD stage 3–5 in the general Asian population.  (<i>Circ J</i> 2014; <b>78:</b> 732–737)<br>

Journal

  • Circulation Journal

    Circulation Journal 78(3), 732-737, 2014

    The Japanese Circulation Society

Codes

  • NII Article ID (NAID)
    130003382240
  • Text Lang
    ENG
  • ISSN
    1346-9843
  • NDL Article ID
    025294136
  • NDL Call No.
    Z54-B860
  • Data Source
    NDL  J-STAGE 
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