Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community

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  • Izumaru Kensuke
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Ninomiya Toshiharu
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Nagata Masaharu
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Usui Tomoko
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Yoshida Daigo
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
  • Yonemoto Koji
    Biostatistics Center, Kurume University
  • Fukuhara Masayo
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Tsuruya Kazuhiko
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kitazono Takanari
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kiyohara Yutaka
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community : The Hisayama Study
  • – The Hisayama Study –

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Abstract

Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3–5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3–5, defined as estimated glomerular filtration rate (eGFR) <60ml·min−1·1.73m−2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3–5. The age- and sex-adjusted incidence of CKD stage 3–5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3–5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR (−0.10ml·min−1·1.73m−2·year−1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3–5 in the general Asian population.  (Circ J 2014; 78: 732–737)<br>

Journal

  • Circulation Journal

    Circulation Journal 78 (3), 732-737, 2014

    The Japanese Circulation Society

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