<i>Candida</i>症の診断と予防を目指した<i>Candida albicans</i>の生化学的解析と分子ディスプレイ技術の応用  [in Japanese] Biochemical Analysis and Application of Molecular Display Technology on <i>Candida albicans</i> for Diagnosing and Preventing Candidiasis  [in Japanese]

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    • 芝崎 誠司 Shibasaki Seiji
    • 兵庫医療大学共通教育センター|兵庫医療大学大学院薬学研究科 General Education Center, Hyogo University of Health Sciences|Graduate School of Pharmacy, Hyogo University of Health Sciences
    • 青木 航 Aoki Wataru
    • 京都大学大学院農学研究科応用生命科学専攻 Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
    • 植田 充美 Ueda Mitsuyoshi
    • 京都大学大学院農学研究科応用生命科学専攻 Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University


  Medical facilities and advances in therapeutics have improved world over in recent times. Concomitant with this, the human population has been growing steadily. However, emerging infectious diseases such as severe acute respiratory syndrome (SARS) and AIDS, as well as re-emerging infectious diseases such as Japanese encephalitis and dengue fever, have been spreading in recent times. Three major infectious diseases, namely AIDS, malaria, and tuberculosis, are killing around 8 million people in the world annually. Although drugs effective against these infectious diseases are available at present, drastic therapeutics have not been developed yet. In addition, vaccines against these diseases often cannot prevent infections, because pathogenic viruses or bacteria evade the immune system of the host. Many diseases and emerging infections of pathogenic bacteria cannot be controlled by conventional pharmaceutics. These pathogens secrete regulatory factors. When the produced regulatory factor attains a certain level, an active factor is then produced by the pathogen to destroy the host. Considering these phenomena, we thought investigating characteristic regulatory or active factors will pave the way for developing novel vaccines or diagnostic drugs. Therefore, candidiasis was selected as a model, and application of the secretory protease of <i>Candida albicans</i> was examined for the development of novel drugs. Screening of novel candidates of antigens of <i>C. albicans</i> and vaccine development are also underway. In this paper, our strategy of platform technology against various infectious diseases are introduced.<br>



    YAKUGAKU ZASSHI 133(11), 1145-1151, 2013

    The Pharmaceutical Society of Japan


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