眼組織における低照射エネルギー超音波の利用  [in Japanese] Application of Ultrasound-enhanced Gene and Drug Delivery to the Ocular Tissue  [in Japanese]

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Author(s)

    • 園田 祥三 Sonoda Shozo
    • 鹿児島大学大学院医歯学総合研究科眼科学 Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences
    • 山下 敏史 Yamashita Toshifumi
    • 鹿児島大学大学院医歯学総合研究科眼科学 Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences
    • 鈴木 亮 [他] Suzuki Ryo
    • 帝京大学薬学部薬物送達研究室 Laboratory of Drug and Gene Delivery, Faculty of Pharma-Sciences, Teikyo University
    • 丸山 一雄 Maruyama Kazuo
    • 帝京大学薬学部薬物送達研究室 Laboratory of Drug and Gene Delivery, Faculty of Pharma-Sciences, Teikyo University
    • 坂本 泰二 Sakamoto Taiji
    • 鹿児島大学大学院医歯学総合研究科眼科学 Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences

Abstract

  Visual images provide an immensely rich source of information about the external world. Eye has characteristic structure sensory cells are arranged along the eye wall, and is filled inside with vitreous body. In recent years, intravitreal injection of anti-vascular endothelial growth factor (VEGF) agent had widely spread, and numerous number of patients who suffered ocular angiogenic disease such as diabetic retinopathy, age-related macular degeneration and retinal vascular occlusion for the disease, were treated and spared the blindness. Vitreous cavity was regarded as reservoir of drug, intravitreal injection is thought a sort of drug delivery. However, with regard to the administration of a selective drug deliver, it has not yet been solved. Our aim is to establish a new method of gene transfer, drug delivery using low-energy ultrasound to the eye, to date, we confirmed drug and gene deliver to the ocular tissue such as cornea, conjunctiva and retina with high efficiency. In addition, tissue damage was minimal. We have also shown that ultrasound irradiation with combination of a microbubbles or bubble liposome could be introduced drug and gene more effectively. Based on these knowledge, we will focus on development of a new device for intraocular ultrasound exposure and potential for therapeutic application of ultrasound to humans retinal disease such as retinal artery obstruction.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133(12), 1269-1276, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003382278
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    025057355
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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