小脳B型γ-アミノ酪酸受容体活性化による視機性動眼反射順応の変調  [in Japanese] Activation of Cerebellar B-type γ-aminobutyric Acid Receptor Modulates Optokinetic Reflex Adaptation  [in Japanese]

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Author(s)

    • 白井 義啓 Shirai Yoshihiro
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama
    • 篠島 俊史 Sasajima Toshifumi
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama
    • 内山 周 [他] Uchiyama Shu
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama
    • 竹腰 昌広 Takegoshi Yoshihiro
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama
    • 津島 永吉 Tsushima Eikichi
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama
    • 田端 俊英 Tabata Toshihide
    • 富山大学大学院理工学研究部(工学)神経情報工学研究室 Laboratory for Neural Information Technology, Graduate School of Sciences and Engineering, University of Toyama

Abstract

  The cerebellar cortex, the brain region responsible for motor coordination and learning expresses a high density of B-type γ-aminobutyric acid receptor (GABAbR). Previous <i>in vitro</i> and <i>in situ</i> studies indicated that cerebellar GABAbR may mediate multiple forms of inhibitory and excitatory modulation of cerebellar circuits. Nevertheless, the <i>in vivo</i> influence of cerebellar GABAbR activation is unclear. As the first step in addressing this issue, we examined how pharmacological activation of cerebellar GABAbR modulates optokinetic reflex (OKR), an involuntary cerebellum-dependent eye movement for stabilizing the retinal image against the drift of the visual scene. We injected baclofen, a GABAbR-selective agonist, or control saline into the cerebellar flocculi of adult mice and then performed 1-h OKR measurement sessions on two consecutive days. In the day 1 session, the baclofen (5 n<small>M</small>)-injected mice and control mice showed similar initial OKR gains and similar training-induced increases in the OKR gain (OKR adaptation). This result suggests that GABAbR activation does not affect cerebellar computation for executing OKR and formation of short-term memory for OKR adaptation. At the beginning of the day 2 session, the baclofen (5 n<small>M</small> or 50 μ<small>M</small>)-injected mice showed an OKR gain higher than that achieved in the day 1 session while the control mice did not. This result suggests that GABAbR activation may facilitate the formation of OKR adaptation-related long-term memory. These findings provide a new insight into the functional architecture of the cerebellar circuits and indicate GABAbR to be a new target of pharmacological therapy against diseases with cerebellar dysfunction.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 134(3), 439-445, 2014

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130003382316
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    025300945
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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