Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

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著者

    • CHOI Sungjin CHOI Sungjin
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan|Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • LIU I-Li CHUNG Ung-il
    • Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan|Department of Bioengineering, School of Engineering, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • YAMAMOTO Kenichi [他] SASAKI Nobuo
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
    • MOCHIZUKI Manabu
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
    • LIU I-Li
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
    • YAMAMOTO Kenichi
    • Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • HONNAMI Muneki
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan|Department of Bioengineering, School of Engineering, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • SAKAI Takamasa
    • Department of Bioengineering, School of Engineering, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • OHBA Shinsuke
    • Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • ECHIGO Ryosuke
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
    • SUZUKI Shigeki
    • NEXT21 K.K., 3–38–1 Hongo, Bunkyo-ku, Tokyo 113–0033, Japan
    • NISHIMURA Ryouhei
    • Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

抄録

We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone<sup>®</sup>) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone<sup>®</sup> (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control group). Computed tomography (CT) was performed at 0, 4 and 8 weeks after implantation. Micro-CT and histological analysis were conducted to measure the non-osseous tissue rate and the area and distribution of new bone tissue in the defect at 8 weeks after implantation. On CT, β-TCP was gradually resorbed, while Tetrabone<sup>®</sup> showed minimal resorption at 8 weeks after implantation. On micro-CT, non-osseous tissue rate of the control group was significantly higher compared with the β-TCP and Tetrabone groups (<i>P</i><0.01), and that of the β-TCP group was significantly higher compared with the Tetrabone group (<i>P</i><0.05). On histology, area of new bone tissue of the β-TCP group was significantly greater than those of the Tetrabone and control groups (<i>P</i><0.05), and new bone distribution of the Tetrabone group was significantly greater than those of the β-TCP and control groups (<i>P</i><0.05). These results indicate differences in biodegradability and connectivity of intergranule pore structure between study samples. In conclusion, Tetrabone<sup>®</sup> may be superior for the repair of large bone defects in dogs.

収録刊行物

  • The Journal of Veterinary Medical Science

    The Journal of Veterinary Medical Science 76(2), 229-235, 2014

    公益社団法人 日本獣医学会

各種コード

  • NII論文ID(NAID)
    130003382365
  • NII書誌ID(NCID)
    AA10796138
  • 本文言語コード
    ENG
  • ISSN
    0916-7250
  • NDL 記事登録ID
    025297003
  • NDL 請求記号
    Z18-350
  • データ提供元
    NDL  J-STAGE 
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