Effect of Pravastatin on Echocardiographic Circulation Parameters in Dogs

• ARITA Shinji

  Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4–101 Koyama-Minami, Tottori 680–8553, Japan Arita Sougo Animal Hospital, 1–14–6 Nishi, Hachihonmatsu, Higashihiroshima, Hiroshima 739–0147, Japan

• ARITA Noboru

  Arita Sougo Animal Hospital, 1–14–6 Nishi, Hachihonmatsu, Higashihiroshima, Hiroshima 739–0147, Japan

• HIKASA Yoshiaki

  Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4–101 Koyama-Minami, Tottori 680–8553, Japan

Abstract

The purpose of this study was to determine the effect of pravastatin (PS) on hemodynamic parameters in healthy dogs. Five beagle dogs were repeatedly used in each of the 4 groups. One group was not medicated (control). Dogs in other groups received 0.5, 1.0 or 2.0 mg/kg PS orally q24hr, for 4 weeks. Physical examination, blood biochemical tests, blood pressure measurements and Doppler echocardiography were performed before and 1, 2 and 4 weeks after PS administration in all dogs. PS significantly reduced the left atrial-to-aortic diameter ratio (LA/Ao), early diastolic transmitral flow (E) wave, E/early diastolic mitral annulus motion velocity (Em) ratio, left ventricular (LV) fractional shortening, LV ejection fraction, mid systolic myocardial velocity gradient, stroke volume (SV), cardiac output (CO), right and left ventricular Tei indices and elevated Em and early diastolic myocardial velocity gradient. Heart rate was not significantly altered during PS administration, but mean blood pressure decreased slightly. The hematological and blood biochemical values were within normal limits during PS administration. These results revealed that PS administration increases LV expansion capacity and decreases LV constriction and left atrial pressure. It has been suggested that PS may be effective in improving heart failures with LV diastolic dysfunction or elevated left atrial pressure in dogs.

Journal

• Journal of Veterinary Medical Science

  Journal of Veterinary Medical Science 76 (4), 481-489, 2014

  JAPANESE SOCIETY OF VETERINARY SCIENCE

Keywords

• canine
• cardiac function
• echocardiography
• hemodynamics
• pravastatin

Details

• CRID: 1390282681407555200
• NII Article ID: 130003382398
• NII Book ID: AA10796138
• DOI: 10.1292/jvms.13-0505
• COI: 1:STN:280:DC%2BC2c3ks1entA%3D%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL BIB ID: 025510076
• PubMed: 24317157
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025510076
• Web Site: https://www.jstage.jst.go.jp/article/jvms/76/4/76_13-0505/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014272026
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed