<i>Notch2</i> Transduction by Feline Leukemia Virus in a Naturally Infected Cat
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Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline <i>Notch2</i> transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring <i>Notch2</i> in the <i>env</i> gene. <i>Notch2</i> was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of <i>Notch2</i> strongly correlates with FeLV-induced lymphoma.
- Journal of Veterinary Medical Science
Journal of Veterinary Medical Science 76(4), 553-557, 2014
JAPANESE SOCIETY OF VETERINARY SCIENCE