Liver Hydrolysate Assists in the Recovery From Physical Fatigue in a Mouse Model
-
- Nakagawasai Osamu
- Department of Pharmacology, Tohoku Pharmaceutical University, Japan
-
- Yamada Kotaro
- Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Japan
-
- Nemoto Wataru
- Department of Pharmacology, Tohoku Pharmaceutical University, Japan
-
- Fukahori Masahiro
- Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Japan
-
- Tadano Takeshi
- Laboratory of Environmental and Health Sciences, College of Medical Pharmaceutical and Health Sciences, Kanazawa University, Japan
-
- Tan-No Koichi
- Department of Pharmacology, Tohoku Pharmaceutical University, Japan
この論文をさがす
抄録
It is reported that liver hydrolysate (LH) enhances liver function. However, the effects of LH on physical fatigue are unknown. The aim of this study was to investigate the effect of LH on alterations in locomotor activity and energy metabolism such as 5′-AMP-activated protein kinase (AMPK), glycogen content, and blood lactic acid, after forced walking. Adult male ddY mice were used. Locomotor activity, AMPK phosphorylation, and glycogen content in the liver and soleus muscle, as well as blood lactic acid were determined following LH treatment before and/or after forced walking. The locomotor activity significantly decreased after forced walking for 3 h. Two administrations of LH (30 or 100 mg/kg) significantly increased the locomotor activity, while a single administration either before or after forced walking did not show any specific effect. Administering LH twice activated AMPK in the liver and soleus muscle. Glycogen levels significantly decreased in both the liver and soleus muscle after forced walking, whereas the blood lactate level significantly increased. In contrast, administering LH twice increased muscle glycogen and decreased blood lactic acid. These findings indicate that LH produced an anti-fatigue effect and that this effect appears to involve the efficient glycogen utilization through activation of AMPK.
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 123 (4), 328-335, 2013
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680157611776
-
- NII論文ID
- 130003382612
-
- NII書誌ID
- AA11806667
-
- COI
- 1:CAS:528:DC%2BC2cXktlOrug%3D%3D
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 025109202
-
- PubMed
- 24257438
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可