Current Perspective : Dual Role of Nitric Oxide in Pancreatic β-Cells
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- Kurohane Kaneko Yukiko
- Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan
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- Ishikawa Tomohisa
- Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan
書誌事項
- タイトル別名
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- Dual Role of Nitric Oxide in Pancreatic <i>β</i>-Cells
- Dual Role of Nitric Oxide in Pancreatic β-Cells
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抄録
An involvement of inducible nitric oxide (NO) synthase (NOS) in pancreatic β-cell degeneration during the process of type 1 diabetes has been well discussed. Recently, there is growing evidence for pivotal roles of constitutive NOS (cNOS) in β-cells; the presence of NOS1 and NOS3 in pancreatic β-cells and the effects of low-concentration NO, which is assumed to be derived from cNOS, on β-cell functions have been reported. However, the roles of cNOS-derived NO in β-cells are still under debate. One of the reasons seems to be that NO has multiple biological activities, which are dependent on its concentration. In β-cells, NO has been shown to exert positive and negative regulation of insulin secretion and anti- and pro-apoptotic activities, which is likely to be dependent on concentrations. In this review article, we will describe the current understanding of the roles of NO in pancreatic β-cells, especially focusing on cNOS-derived NO and its differential roles depending on concentrations.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 123 (4), 295-300, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180881536
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- NII論文ID
- 130003382623
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXktlOksw%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025108976
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- PubMed
- 24285083
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可