Biotransistor with Functional Nanointerface Containing Biomolecules
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- Tabata Miyuki
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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- Goda Tatsuro
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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- Matsumoto Akira
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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- Miyahara Yuji
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Bibliographic Information
- Other Title
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- 機能性ナノ界面を有するバイオトランジスタ
Abstract
The convergence of nano-/bio- technology with biomedicine has occurred tremendously over the last few decades. In particular, next-generation biosensors offer great potential to treat serious medical problems in the fields of diagnostics, therapy, and drug delivery. Advantageously, an electrical biosensor platform composed of target-capturing element and semiconductor device as a signal transducer is compatible with a high-throughput analysis via miniaturization and integration into a small chip for decentralized bioanalytical applications. So far, we have successfully achieved potentiometric biosensing based mostly on a direct readout of innately charged biomolecules using field effect transistor (FET). Highly specific molecular recognition is available by constructing engineered biointerface on the sensor. Furthermore, the potentiometric technique provides the ability to perform label-free and real-time detection for various biomolecules. These features would help to promote personalized medicine for individual patients in the future. Here we describe fundamental aspects of electrical biosensing and review recent developments of the FET-based biotransistors.
Journal
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- IEEJ Transactions on Sensors and Micromachines
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IEEJ Transactions on Sensors and Micromachines 133 (11), B314-B319, 2013
The Institute of Electrical Engineers of Japan
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Details 詳細情報について
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- CRID
- 1390282679437735040
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- NII Article ID
- 130003382691
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- ISSN
- 13475525
- 13418939
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed