乳酸菌の免疫調節効果に関する研究  [in Japanese] Effects of lactic acid bacteria on immune regulatory activities  [in Japanese]

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Abstract

乳酸菌の中には宿主の免疫応答を刺激する作用を有するものがあり,種々の免疫関連疾患に対する改善効果が考えられることから,実用化を目的としてその有用性を検証した.Th1/Th2バランスを是正する免疫調節活性の高い<i>L. gasseri</i> OLL2809を選出し,その有効性を評価すると抗原特異的IgEの抑制効果や好酸球増多に対する抑制効果が認められた.同株を用いてスギ花粉症罹患者を対象に臨床試験を実施したところ,鼻づまり等の鼻症状が軽減された.その他の免疫関連疾患として,NK活性との関連が示唆される子宮内膜症に対しては,モデル動物において病変部の成長抑制効果が認められた.さらに,子宮内膜症罹患者を対象に有効性を臨床評価したところ,主症状である月経痛に軽減が認められた.以上の一連の研究から,高い免疫調節活性を示すOLL2809株は,アレルギーや子宮内膜症等の免疫関連疾患に対して症状の軽減等に有効であり,罹患者のQOLの向上に貢献できることが明らかになった.<br>

The effect of a lactic acid bacterium on diseases caused by immune disorders was evaluated in this study with the aim of developing practical uses for it as a food product. A potential probiotic strain, <i>Lactobacillus gasseri</i> OLL2809, which exhibits a strong immunomodulatory effect, was selected using an allergic mouse model. The oral administration of this strain reduced antigen-specific immunoglobulin E levels and cedar pollen-induced eosinophilia in mice. In addition, a clinical trial revealed reduction of nasal symptoms in patients with Japanese cedar pollinosis. Furthermore, the effect of this strain on endometriosis, which is associated with aberrant immune states in the peritoneal cavity, was assessed. The results show that oral administration of the strain reduced development of endometriotic regions in the endometriosis mouse model. Moreover, a clinical trial involving patients with endometriosis revealed that <i>L. gasseri</i> OLL2809 was effective against endometriosis, especially against menstrual pain and dysmenorrhea. These results suggest that a potential probiotic, <i>L. gasseri</i> OLL2809, alleviates various immune-related diseases by modulating the immune system, facilitating improvements in our quality of life.<br>

Journal

  • Journal of Intestinal Microbiology

    Journal of Intestinal Microbiology 27(4), 197-202, 2013

    JAPAN BIFIDUS FOUNDATION

Codes

  • NII Article ID (NAID)
    130003383393
  • Text Lang
    JPN
  • ISSN
    1343-0882
  • Data Source
    J-STAGE 
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